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Natural Progesterone Cream
Natural Progesterone Cream
Natural Progesterone Cream
Natural Progesterone Cream
Natural Progesterone Cream

Natural Progesterone Cream

Supports healthy balance*

Regular price $25.95 Sale


Dr. John Lee's best selling book lists the following benefits of natural progesterone:*

  • Restores sex drive
  • Help maintain healthy moods
  • Facilitates thyroid hormone action
  • Normalizes zinc and copper levels
  • Helps the body use fat for energy
  • Improves sleep patterns
  • Restores proper oxygen cell levels
  • Natural diuretic


What is Natural Progesterone Cream?

For the last 30 years, Dr. John Lee has been advocating the use of progesterone cream in menopausal and pre-menopausal women. We’ve developed Natural Progesterone Cream based on Dr. Lee’s research. Our progesterone cream contains bioidentical USP micronized progesterone, with 500 mg per ounce. 

We also offer other progesterone products such as Natural Progesterone Gel and Healthy Progesterone Cream.

What does Natural Progesterone Cream do?

Women throughout the world are becoming better acquainted with the health benefits of natural progesterone. Natural Progesterone reduces the symptoms and discomfort of Menopause, PMS, and Premenopause without the side effects often associated with synthetic hormone replacement therapy. *

Do not confuse Natural Progesterone with dangerous progestins hyped by the pharmaceutical industry. We refer only to natural progesterone exactly like your body produces in abundant quantities during pregnancy.

What is Menopause?

Menopause is normally defined as the end of menstrual cycles. The unpleasant symptoms of menopause that some women suffer, such as hot flashes, vaginal dryness, and mood swings are peculiar to western industrialized societies.

For some, menopause is associated with the end of a woman’s sexuality and the beginning of old age, and arthritis, but it doesn’t have to be that way!

What does Progesterone have to do with Menopause?

A woman's ovaries make two hormones: estrogen and progesterone. When these hormones are out of balance, hormone-related illnesses can emerge. Due to ovulatory cycles, progesterone levels typically decline before menopause starts, in turn, it is followed by a decline in estrogen. Progesterone production tends to fall to almost zero while estrogen declines to about 40% to 50%. This situation leads to an imbalance between estrogen and progesterone causing an increase in estrogen activity, something now described as estrogen dominance.

Progesterone Supplementation

Many women find that by supplementing their hormone production with natural progesterone they will reduce many or most of their menopausal symptoms.* The presence of progesterone in the body sensitizes estrogen receptor sites thus enabling estrogen to work more efficiently. Progesterone is a precursor to other hormones in the body including estrogen, testosterone, and especially the corticosteroids.

Progesterone is one of two main hormones, the other being estrogen, made by the ovaries of menstruating women. Progesterone is also made in smaller amounts by the adrenal glands in both sexes and by the testes in males. When a woman's monthly cycle is functioning correctly, estrogen is the dominant hormone during the first two weeks of the menstrual cycle. In response to ovulation, progesterone assumes dominance for the final two weeks of the month. When the pituitary gland in the brain sends a message to the ovaries to stop production of progesterone, the menstrual cycle begins within 48 hours of this message.

Supplement Spot’s Natural Progesterone Cream offers safe, gentle relief from your menopausal symptoms while moisturizing your skin with natural oils.*

Suggested Use

Apply to soft areas such as the inner arms, chest, or neck. Rotate application area daily to avoid saturation.

Pre-menopausal women: Apply 1-2 pumps twice a day, 14 days before expected menses, discontinue use 1-2 days before menses and start again 10-12 days after menses (counting the first day of menstruation as Day 1).

Post-menopausal women: Apply 1-2 pumps twice a day for 25 consecutive days and discontinue use for 5 consecutive days.

Each full press of the pump dispenses about 17 mg progesterone.


Deionized Water, Aloe Vera, Almond Oil, Caprylic/Capric Triglycerides, Glycerin, Polysorbate 60, Stearic Acid, Cetyl Alcohol, Coconut Oil, Glyceryl Stearate, Phenoxyethanol, Retinol A, Progesterone, Shea Butter, Beeswax, Vitamin E, Triethanolamine


For external use only. Do not use on sores or wounds. Discontinue use if irritation develops. Avoid contact with eyes.

As always, consult your physician before using this product, especially if you have a medical or psychiatric condition, or are pregnant or lactating.

These statements have not been evaluated by the FDA.  This product is not intended to diagnose, prevent, treat, or cure any disease.*

Customer Reviews

Based on 4 reviews
joi shields

Natural Progesterone Cream

Bernadette Mullenix

I have been using this product for many years and it is very effective. Works great for me and I would recommend it highly. I give it 5 stars for how it still works for me after using it for a few decades I started using it after I read Dr John R Lee's book; "What Your Doctor May Not Tell You About Menopause". I also recommend reading his book about Menopauses and Natural Progesterone. Very informative and helpful.

I began using this Natural Progesterone Cream when I was going through the throes of Menopause.

I am still using it 18 years later. It has made a huge difference in my feeling of well being and clarity of thinking. I highly recommend it!!

Your progesterone cream has been a godsend.

And the lady who took my order and answered my questions was wonderful. I will buy again... and again and again.