Why take Life Extension’s Bone Restore
Throughout life, cells known as osteoblasts construct bone matrix and fill it with calcium. At the same time, osteoclasts work just as busily to tear down and resorb bone. This fine balance is regulated by many factors, including systemic hormones and cytokines. Bone mass reaches its peak by the middle of the third decade of life and plateaus for about ten years, during which time bone turnover is constant, with bone formation approximately equaling bone resorption.1,2
As our bodies age, this fine balance of osteoblasts (building of bones) and asteoclasts (tear down of bones) is lost. As the hormone levels shift in midlife (more in women than in men) the osteoclasts gain the upper hand and bone mass begins to lessen. Some bone integrity is already being lost by the time women reach menopause, but the rate of loss can increase up to tenfold during the first five years after menopause. 1-3
Bone density loss is not only associated with calcium deficiency, but also with a lacking in nutrients4-11 such as magnesium10,11 and vitamin D3. 12,13 In order for calcium to help maintain healthy bone structure, healthy amounts of manganese,8 vitamin D3, zinc, 14,15 magnesium, 16 and other nutrients should be available so that calcium and phosphorus can be incorporated into the bone matrix. Life Extension’s Bone Restore also contains boron called, FruiteX B® OsteoBoron®. It is calcium/carbohydrate/boron complex, similar to what is found in fruits and vegetables and is more bioavailable than boron citrate.
Calcium supplements are best taken with meals. To enhance solubility, Calcium should be taken with water or juice. 17 If calcium-containing formulas, such as Bone Store, are taken only once daily, it may be best taken at night.18
References 1. Rheum Dis Clin N Am 33 (2007) 149-176 2. Eur J Clin Invest. 1988 Oct;18(5):529-34. 3. Bone. 2001 Mar;28(3):327-31. 4. Magnes Trace Elem. 1990;9(2):61-9. 5. Curr Pharm Des.2003;9(32):2687-704. 6. Ann Nutr Metab. 2002;46(6):249-53. 7. J Int Med Res. 2007 Sep-Oct;35(5):692-5. 8. J Nutr. 1994 Jul;124(7):1060-4. 9. Crit Rev Food Sci Nutr. 2006;46(8):621-8. 10. Magnes Res. 1993 Jun;6(2):155-63. 11. J Reprod Med. 1990 May;35(5):503-7. 12. J Clin Endocrinol Metab. 2010 Jun;95(6):2630-3. 13. Am J Clin Nutr. 1995 Mar;61(3 Suppl):638S-45S. 14. Ann Nutr Metab. 2009;54(3):218-26 15. Toxic Sci. 2006 Jul;92(1):286-94 16. PDR for Nutritional Supplements, 1st ed. Montvale, NJ: Medical Economics Co.; 2001:288-95. 17. Osteoporos Int. 1991 Feb;1(2):65-71. 18. J Clin Endocrinol Metab. 1994 Sep;79(3):730-5.
Servings per Container: 30
|Amount per Serving||% Daily Value|
|Vitamin D3 (as cholecalciferol)||1000 IU||250%|
|Calcium (as DimaCal® dicalcium malate, TRAACS® calcium bisglycinate chelate, calcium fructoborate)||700 mg||70%|
|Magnesium (as magnesium oxide)||300 mg||75%|
|Zinc (as zinc amino acid chelate)||2 mg||13%|
|Manganese (as manganese amino acid chelate)||1 mg||50|
|HMRlignan™ Norway spruce (Picea abies) lignan extract (knot wood) [standardized to 90% Hydroxymatairesinol potassium acetate (50 mg)]||56 mg||**|
|Silicon [from horsetail (Equisetum arvense) extract (herb)]||5 mg||**|
|Boron (calcium fructoborate as patented Fruitex B® OsteoBoron®)||3 mg||**|
** Daily Value has not been established.
Other ingredients: vegetable cellulose (capsule), vegetable stearate, maltodextrin, corn starch.
Fruitex B® and OsteoBoron® are registered trademarks of VDF Futureceuticals, Inc. U.S. Patent No. 5,962,049.
DimaCal® and TRAACS® are registered trademarks of Albion Laboratories, Inc.
Malate is covered by U.S. Patent 6,706,904 and patents pending.
Take four (4) capsules daily, or as recommended by a healthcare practitioner.
Scientific studies suggest calcium supplementation in divided doses with food in the morning and evening may yield the best results.
Maintaining an optimal vitamin D blood level also helps maximize calcium absorption.
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.