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In a study of 3,385 Japanese-American men living in Hawaii, scientists looked at the health records of men aged 71 to 93 years and ascertained their use of Vitamin C and Vitamin E. "We found that combined Vitamin E and C supplement use was associated with a reduction of 88 percent in the frequency of subsequent vascular dementia," or memory loss associated with blood vessels, eight researchers reported in the medical journal Neurology, a publication of the American Academy of Neurology. "In separate analyses limited to non-demented subjects," they said, "use of either Vitamin E or C supplements alone ... was associated significantly with better cognitive test performance ... " The study, part of the ongoing Honolulu-Asia Aging Study being conducted at the University of Hawaii and other locations, suggested that "long-term use is required to improve cognitive function in late life." Citing previous studies that suggested a combination of Vitamin E and C might provide more antioxidant effect that either alone, the researchers said that in their current study "there was a strong interaction between Vitamin E and C in promoting cognitive performance. It has been suggested, they reported, that a higher level of Vitamin C can increase Vitamin E levels. "The study has many strengths," the researchers concluded, pointing out that the test subjects have been under medical surveillance for more than 25 years and that participation rates were high. The study population, Japanese-American men, is known to have high rates of stroke. The researchers said their findings supported earlier studies concluding that antioxidant vitamins can slow progression of dementia, or memory loss, and recommended a "primary prevention trial" to examine the potential protective effects of both vascular dementia and Alzheimer's dementia. No protective effect was found for Alzheimer's in the current study.
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