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Why Pregnenolone?

Most people who use hormone supplements are familiar with DHEA but the less known hormone supplement, Pregnenolone, is definitely worth considering. Pregnenolone is known as the parent of all hormones. All other sex hormones are derived from it, including DHEA. By age 75 we produce only about 40% of our youthful levels.

Pregnenolone is the first hormone that generates a range of neurohormones in the brain which are known to affect nerve cell growth and to modulate mood. Pregnenolone therefore has a dominant effect in a wide range of nervous system functions, including memory function, alertness and well-being. Increasing cognitive function is key goal to any aging person. As pregnenolone production falls, ensuring healthy levels may factor into an aging adult’s cognition. The conversion of cholesterol to pregnenolone is the first of many steps in the synthesis of some of our body’s key hormones, including DHEA, progesterone, estrogen, testosterone, and cortisol.

Pregnenolone also operates as a powerful neurosteroid in the nervous system1,2. By supplementing with pregnenolone, you may be assisting the normalizing levels of neurosteroids in the brain promoting neurogenesis, myelination (insulation to protect the nerve fibers), neuronal survival, improved memory, and a reduction of neurotoxicity3. These discoveries have sparked the research Synaptocrinology, which studies the actions of hormones at nerve junctions (synapses)4.

Supplement Spot carries a variety of Pregnenolone supplement sizes. 50 mg, 100 mg, 150 mg and Triple Hormone, which has 25 mg of Pregnenolone, 25 mg of DHEA and 1 mg of Melatonin.

In conclusion, Pregnenolone may help us keep our thinking caps on as we age and is a definite consideration to our daily supplement routine. Please keep in mind that since Pregnenolone is a hormone, it’s always best to consult your health care professional before taking it.

Live Long and Love Life!

1. Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res. 1997;5:21-32. 2. Dubrovsky BO. Steroids, neuroactive steroids and neurosteroids in psychopathology. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):169-92. 3. Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther. 2007 Jun 16. 4. Mukai H, Takata N, Ishii HT, et al. Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology. Neuroscience. 2006;138(3):757-64.